{"id":24039,"date":"2021-02-12T17:58:01","date_gmt":"2021-02-12T17:58:01","guid":{"rendered":"https:\/\/www.testingforall.org\/?p=24039"},"modified":"2021-07-06T22:20:28","modified_gmt":"2021-07-06T21:20:28","slug":"understanding-your-roche-anti-sars-cov-2-s-test-result","status":"publish","type":"post","link":"https:\/\/www.testingforall.org\/understanding-your-roche-anti-sars-cov-2-s-test-result\/","title":{"rendered":"Understanding your Roche Anti-SARS-CoV-2 (S) test result"},"content":{"rendered":"
Last updated 6th July 2021.<\/p>\n
This article explains the result from the Roche Anti-SARS-CoV-2 (S) test to give Testing For All users a better understanding of how this diagnostic test works. The aim of this product is to help the Testing For All community to understand their immune response, and hence their immunity status to COVID-19. For those that wish to, this test can also be used to monitor your antibody level (or antibody titer as it is more formally known) over time as the test provides a calibrated result in U\/mL that will change as your IgG antibody level builds and then wanes over an extended period of time.<\/span><\/p>\n The body has a range of ways to fight off infection, but the scientific community has centred the development of vaccines for COVID on triggering the creation of antibodies to the spike protein of coronavirus. These “spikes” are what gives coronaviruses their name, and it is through this spike mechanism that the virus binds to healthy human cells in order to replicate itself. A natural infection creates a wide ranged defence, often involving a T cell response to destroy human cells infected by SARS-SoV-2 to stop virus from replicating, and by the creation of a range of antibodies to different proteins in the virus that attempt to deactivate it before it can bind to host cells. The original COVID-19 Home Total Antibody Test<\/a> we launched in Sept 2020 detects antibodies to the Nucleocapsid protein that surrounds the RNA of the coronavirus, and is useful for detecting previous exposure, which has provided many people with an understanding of whether past or ongoing symptoms that they experienced were related to a coronavirus infection that occurred before PCR testing was widely available.<\/p>\n The COVID-19 Immunity Test<\/a> provides an accurate calibrated measurement of the level of antibodies to the spike protein, and is therefore considered to be a good view of your immune response and status.\u00a0 In the testing that we have carried out with our laboratory partner, we have compared the result of the both the Roche N and S test tests on positive blood samples and see very good agreement so if you tested positive on our COVID-19 Home Total Antibody Test then you will very likely test positive on the COVID-19 Immunity Test. The difference between the two tests is that they are looking at different viral protein targets, and that the Immunity Test gives you a calibrated antibody titer that can be compared to other tests and the emerging WHO standard.<\/p>\n The Roche Anti-SARS-CoV-2 (S) test will return “< 0.4” (less than o.4) in the case where the response is below the instrument’s limit of detection, meaning that this sensitive instrument could not detect any neutralising antibodies. This is the most common result for negative responses, with 97% of negative tests to date returning this result.<\/span><\/p>\n Positive results are greater than 0.8, with the upper bound listed as “> 2,500” or greater than 2,500. Those that receive a result of > 2,500 have a neutralising antibody response of at least 2,500 U\/mL indicating a very high antibody level.<\/p>\n In the period 12th Feb to 12th June 2021 Testing For All completed 3,016 quantitative Anti-SARS-CoV-2 (S) <\/span>tests. The range of results is shown below:<\/p>\nWhat is the range of results?<\/strong><\/h2>\n